Medical Research
Phenotypic detection combined with single-cell analysis enhances detection speed and accuracy, driving advancements in medical research.
The evolving landscape of modern medical research demands greater precision—shifting from cell populations to single-cell analysis—and more intuitive methodologies, transitioning from genotype-based to phenotype-driven approaches. Multimodal phenotypic detection, combined with single-cell analysis and sorting technologies, offers powerful and precise tools for biomedical research, enhancing both accuracy and depth in scientific exploration.
The P300 Laser Confocal Raman Spectrometer has been instrumental in applications such as rapid pathogen detection, tumor pathology analysis, pharmacological evaluation, and medical material characterization, demonstrating strong potential for rapid diagnostic applications.
The S3000 Ultrafast 3D Fluorescence Imaging System delivers cutting-edge confocal imaging technology for pathology and pharmacology studies, biomarker screening, and immunological mechanism research.
The PRECI SCS Single-Cell Sorter enables the rapid detection of circulating tumor cells and supports high-precision single-cell tranomic studies.
By integrating phenotypic detection and single-cell analysis, these advanced technologies are equipping biomedical research with new tools and strategies, driving progress in precision medicine.
-
Multimodal Phenotyping
-
Culture-Free Rapid Detection
-
Single-Cell Precise Analysis
-
Ultra-fast 3D Imaging
Exploration
-
Pathogenic Bacteria Detection
Pathogenic Bacteria DetectionSingle-cell raman spectroscopy integrated with deep learning for the Rapid Classification and Identification of Pathogenic Microorganisms.
Learn More
-
Antimicrobial Resistance Detection
Antimicrobial Resistance DetectionRapid Culture-Free antimicrobial susceptibility testing via D₂O-Raman combination.
Learn More
-
Pathological Study
Pathological StudyThrough high-precision analysis of changes in cellular composition and metabolic patterns within lesion areas, we aim to comprehensively elucidate pathological mechanisms and precisely delineate the disease progression trajectory.
Learn More
Biological Raman Spectroscopy Detection Solution
Raman spectroscopy, known for its features of label-free, non-invasive, real-time, and rapid detection, presents significant potential in biomedical research. To address the unique characteristics of biological samples, Hooke Instruments Ltd. has developed the P300 Laser Confocal Raman Spectrometer, featuring advanced single-cell detection capabilities. This instrument delivers comprehensive enhancements in sensitivity, accuracy, stability, and reliability, providing a complete solution for diverse applications, including culture-free antimicrobial susceptibility testing, rapid pathological tissue analysis, cellular metabolism monitoring, stem cell differentiation tracking, and drug metabolism research.
Ultrafast 3D Fluorescence Imaging Solution
In biomedical research, observing the fine structures of cells and tissues is essential. The Hooke S3000 Ultrafast 3D Fluorescence Imaging System utilizes spinning disk confocal imaging technology, increasing traditional 3D imaging speeds by tens of times. By enabling high-definition, dynamic cellular imaging, it significantly enhances research efficiency and provides vital data support for medical research in oncology, pathology, genetics, immunology, toxicology, pharmacology, and other fields.
High-Precision Single-Cell Sorting Solution
Understanding complex physiological and pathological processes requires analysis at the single-cell level due to cellular heterogeneity. The PRECI SCS Single-Cell Sorter and Scatcher Single-Cell Optical Tweezers Manipulation and Sorting System enable high-precision single-cell isolation. The sorted cells can be cultured or used for tranome sequencing, enhancing research accuracy and depth. This advanced approach provides novel strategies for medical research, including circulating tumor cell screening, tumor heterogeneity studies, and drug candidates screening.
-
International Journal of Nanomedicine|Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model2024.10.16 -
International Journal of Biological Macromolecules|Injectable chitosan-polyvinylpyrrolidone composite thermosensitive hydrogels with sustained submucosal lifting for endoscopic submucosal dissection2024.07.16 -
Foods|Raman−Activated Cell Ejection for Validating the Reliability of the Raman Fingerprint Database of Foodborne Pathogens2024.07.09 -
Pediatric blood & cancer|Serum apelin as a potential biomarker for infantile hemangiomas2024.05.27 -
European Polymer Journal|Chitosan with enhanced deprotonation for accelerated thermosensitive gelation with β-glycerophosphate2024.05.15 -
Frontiers in Bioscience-Landmark Ed|Rapid Detection and Analysis of Raman Spectra of Bacteria in Multiple Fields of View Based on Image Stitching Technique2023.10.31 -
Analyst|A microfluidic immunosensor for automatic detection of carcinoembryonic antigen based on immunomagnetic separation and droplet arrays2023.05.06 -
ACS ChemicalNeuroscience|In Vitro Diagnosis and Visualization of Cerebral Ischemia/Reperfusion Injury in Rats and Protective Effects of Ferulic Acid by Raman Biospectroscopy and Machine Learning2023.04.25 -
Frontiers in Microbiology|Rapid identification and drug resistance screening of respiratory pathogens based on single-cell Raman spectroscopy2023.02.03 -
Computational and Structural Biotechnology Journal|Building an ensemble learning model for gastric cancer cell line classification via rapid Raman spectroscopy2023.01.12 -
Journal of Biophotonics|Classification of pathogenic bacteria by Raman spectroscopy combined with variational auto-encoder and deep learning2023.01.09 -
Analytical Methods|Stain-free Gram staining classification of pathogens via single-cell Raman spectroscopy combined with machine learning2022.10.31 -
Frontiers in Microbiology|Single Cell Raman Spectroscopy Deuterium Isotope Probing for Rapid Antimicrobial Susceptibility Test of Elizabethkingia spp2022.06.02 -
Frontiers in Cell and Developmental Biology|Time-resolved extracellular matrix atlas of the developing human skin dermis2021.11.30 -
Advanced Healthcare Materials|Unraveling an Innate Mechanism of Pathological Mineralization-Regulated Inflammation by a Nanobiomimetic System2021.10.13