Frontiers in Bioengineering and Biotechnology丨Raman Spectroscopy: A Novel Technology for Gastric Cancer Diagnosis
In March 2022, BeiLi's team of researchers from Changchun Institute of Optics and mechanics, Chinese Academy of Sciences, and Qi Zhao's team of associate researchers from cancer prevention and treatment center of Sun Yat sen University published a review article "Raman Spectroscopy: A Novel Technology for Gastric Cancer Diagnosis" in Frontiers in Bioengineering and Biotechnology.
Gastric cancer is usually diagnosed at late stage and has a high mortality rate, whereas early detection of gastric cancer could bring a better prognosis. Conventional gastric cancer diagnostic methods suffer from long diagnostic times, severe trauma, and a high rate of misdiagnosis and rely heavily on doctors' subjective experience. Raman spectroscopy is a label-free molecular vibrational spectroscopy technique that identifies the molecular fingerprint of various samples based on the inelastic scattering of monochromatic light. Because of its advantages of non-destructive, rapid, and accurate detection, Raman spectroscopy has been widely studied for benign and malignant tumor differentiation, tumor subtype classification, and section pathology diagnosis. This paper reviews the applications of Raman spectroscopy for the in vivo and in vitro diagnosis of gastric cancer, methodology related to the spectroscopy data analysis, and presents the limitations of the technique.
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